Next Article in Journal
Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development
Next Article in Special Issue
Physicochemical Characterization, Antioxidant and Immunostimulatory Activities of Sulfated Polysaccharides Extracted from Ascophyllum nodosum
Previous Article in Journal
Correlations of Molecular Weights of β-Glucans from Qingke (Tibetan Hulless Barley) to Their Multiple Bioactivities
Previous Article in Special Issue
Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(7), 1711; https://doi.org/10.3390/molecules23071711

Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells

1
Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
2
Center for Converging Humanities, Kyung Hee University, Seoul 02447, Korea
3
Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungnam 31499, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 11 June 2018 / Revised: 6 July 2018 / Accepted: 12 July 2018 / Published: 13 July 2018
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [1560 KB, uploaded 13 July 2018]   |  

Abstract

Thymic stromal lymphopoietin (TSLP) is an important factor responsible for the pathogenesis of allergic diseases, such as atopic dermatitis and asthma. Because linalyl acetate (LA) possesses a wide range of pharmacological properties, being antispasmodic, anti-inflammatory, and anti-hyperpigmentation, we hypothesized that LA could inhibit TSLP. Therefore, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, caspase-1 assay, Western blot analysis, fluorescent analyses of the intracellular calcium levels, and the phorbol myristate acetate (PMA)-induced edema model were used to investigate how LA inhibits the production of TSLP in HMC-1 cells. LA reduced the production and mRNA expression of TSLP in HMC-1 cells. LA also inhibited the activation of nuclear factor-κB and degradation of IκBα. PMA plus A23187 stimulation up-regulated caspase-1 activity in HMC-1 cells; however, this up-regulated caspase-1 activity was down-regulated by LA. Finally, LA decreased intracellular calcium levels in HMC-1 cells as well as PMA-induced ear swelling responses in mice. Taken together, these results suggest that LA would be beneficial to treatment of atopic and inflammatory diseases by reducing TSLP. View Full-Text
Keywords: thymic stromal lymphopoietin; linalyl acetate; nuclear factor-κB; caspase-1; intracellular calcium thymic stromal lymphopoietin; linalyl acetate; nuclear factor-κB; caspase-1; intracellular calcium
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Moon, P.-D.; Han, N.-R.; Lee, J.S.; Kim, H.-M.; Jeong, H.-J. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells. Molecules 2018, 23, 1711.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top