Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression
AbstractMagnolol, a compound from the traditional Korean herb Magnolia sp., has been exhaustively investigated as a therapeutic agent against several diseases including systemic and local inflammation. We examined the effects of magnolol on osteoclastic differentiation associated with inflammation. Magnolol markedly reduced interleukin (IL)-1-induced osteoclast formation in co-cultures of murine osteoblasts and bone marrow cells, whereas it had no effect on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation in bone marrow macrophage cultures. In osteoblasts, magnolol markedly inhibited both the up-regulation of RANKL expression and the production of prostaglandin E2 (PGE2) in response to IL-1 treatment. Addition of exogenous PGE2 reversed the inhibitory effects of magnolol on IL-1-induced RANKL expression in osteoblasts and osteoclast formation in co-cultures. Magnolol inhibited IL-1-induced PGE2 production, at least in part by suppressing cyclooxygenase-2 (COX-2) expression. Taken together, these results demonstrate that magnolol inhibits IL-1-induced RANKL expression in osteoblasts through suppression of COX-2 expression and PGE2 production, resulting in inhibition of osteoclast differentiation in co-cultures. View Full-Text
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Hwang, Y.-H.; Kim, T.; Kim, R.; Ha, H. Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression. Molecules 2018, 23, 1598.
Hwang Y-H, Kim T, Kim R, Ha H. Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression. Molecules. 2018; 23(7):1598.Chicago/Turabian Style
Hwang, Youn-Hwan; Kim, Taesoo; Kim, Rajeong; Ha, Hyunil. 2018. "Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression." Molecules 23, no. 7: 1598.
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