Next Article in Journal
A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients
Previous Article in Journal
DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 23
Issue 7
10.3390/molecules23071577
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media

by
Bao-Hui Ruan
†,
Shu-Quan Li
†,
Xue-Qiong Yang
,
Ya-Bin Yang
*,
Ya-Mei Wu
,
Li-Jiao Shi
,
Hai-Yue Yin
,
Hao Zhou
and
Zhong-Tao Ding
*
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, 2st Cuihu North Road, Kunming 650091, China
*
Authors to whom correspondence should be addressed.
†
These authors contribute equally to this work.
Molecules 2018, 23(7), 1577; https://doi.org/10.3390/molecules23071577
Submission received: 31 May 2018 / Revised: 25 June 2018 / Accepted: 28 June 2018 / Published: 29 June 2018
(This article belongs to the Section Natural Products Chemistry)
Browse Figures
Versions Notes

Abstract

Stachybotrys sp. PH30583 cultured in liquid medium only led to one structure type of novel isochroman dimers. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Stachybotrys sp. PH30583 cultured in rice solid medium led to the isolation of four triprenyl phenols, including two new bisabosquals and two known phenylspirodrimanes. Nitrobisabosquals A and B (1 and 2) are the first case of pyrrolidone-bisabosquals reported in literature. Totally different compounds were isolated using rice solid medium, compared with those isolated using liquid medium, so that rice solid medium presents a key factor in the production of triprenyl phenols. Compound 1 exhibited cytotoxicity against tumor cells, A-549, HL-60, MCF-7 SMMC-7721, and SW480, as well as weak anticoagulant activity with activated partial thromboplastin time (APTT) of 32.1 ± 0.17 s (p < 0.05 vs. Con.) at a concentration of 5 mM. Triprenyl phenol metabolites could be used as chemotaxonomic markers for Stachybotrys.
Keywords: Stachybotrys sp. PH30583; medium induction; triprenyl phenol; cytotoxicity; anticoagulant activity; chemotaxonomic marker Stachybotrys sp. PH30583; medium induction; triprenyl phenol; cytotoxicity; anticoagulant activity; chemotaxonomic marker
Graphical Abstract

Share and Cite

MDPI and ACS Style

Ruan, B.-H.; Li, S.-Q.; Yang, X.-Q.; Yang, Y.-B.; Wu, Y.-M.; Shi, L.-J.; Yin, H.-Y.; Zhou, H.; Ding, Z.-T. New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media. Molecules 2018, 23, 1577. https://doi.org/10.3390/molecules23071577

AMA Style

Ruan B-H, Li S-Q, Yang X-Q, Yang Y-B, Wu Y-M, Shi L-J, Yin H-Y, Zhou H, Ding Z-T. New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media. Molecules. 2018; 23(7):1577. https://doi.org/10.3390/molecules23071577

Chicago/Turabian Style

Ruan, Bao-Hui, Shu-Quan Li, Xue-Qiong Yang, Ya-Bin Yang, Ya-Mei Wu, Li-Jiao Shi, Hai-Yue Yin, Hao Zhou, and Zhong-Tao Ding. 2018. "New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media" Molecules 23, no. 7: 1577. https://doi.org/10.3390/molecules23071577

APA Style

Ruan, B.-H., Li, S.-Q., Yang, X.-Q., Yang, Y.-B., Wu, Y.-M., Shi, L.-J., Yin, H.-Y., Zhou, H., & Ding, Z.-T. (2018). New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media. Molecules, 23(7), 1577. https://doi.org/10.3390/molecules23071577

Article Metrics

Back to TopTop