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Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
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Molecules 2018, 23(6), 1449; https://doi.org/10.3390/molecules23061449
Received: 16 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 14 June 2018
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented. View Full-Text
Keywords: N-heterocycle; piperidine; pyrrolidine; azetidine; cross-coupling; cobalt; Grignard reagent N-heterocycle; piperidine; pyrrolidine; azetidine; cross-coupling; cobalt; Grignard reagent
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MDPI and ACS Style

Barré, B.; Gonnard, L.; Guérinot, A.; Cossy, J. Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents. Molecules 2018, 23, 1449.

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