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Molecules 2018, 23(5), 1217; https://doi.org/10.3390/molecules23051217

Synthesis and Insecticidal Activity of Mesoionic Pyrido[1,2-α]pyrimidinone Derivatives Containing a Neonicotinoid Moiety

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China
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Received: 12 March 2018 / Revised: 13 May 2018 / Accepted: 14 May 2018 / Published: 19 May 2018
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism. View Full-Text
Keywords: mesoionic; pyrido[1,2-α]pyrimidinones; neonicotinoid; insecticidal activity; proteomic mesoionic; pyrido[1,2-α]pyrimidinones; neonicotinoid; insecticidal activity; proteomic
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Pan, J.; Yu, L.; Liu, D.; Hu, D. Synthesis and Insecticidal Activity of Mesoionic Pyrido[1,2-α]pyrimidinone Derivatives Containing a Neonicotinoid Moiety. Molecules 2018, 23, 1217.

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