Improved Synthesis of N-Methylcadaverine
AbstractAlkaloids compose a large class of natural products, and mono-methylated polyamines are a common intermediate in their biosynthesis. In order to evaluate the role of selectively methylated natural products, synthetic strategies are needed to prepare them. Here, N-methylcadaverine is prepared in 37.3% yield in three steps. The alternative literature two-step strategy resulted in reductive deamination to give N-methylpiperidine as determined by the single crystal structure. A straightforward strategy to obtain the mono-alkylated aliphatic diamine, cadaverine, which avoids potential side-reactions, is demonstrated. View Full-Text
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Anderson, K.N.; Moaven, S.; Unruh, D.K.; Cozzolino, A.F.; D’Auria, J.C. Improved Synthesis of N-Methylcadaverine. Molecules 2018, 23, 1216.
Anderson KN, Moaven S, Unruh DK, Cozzolino AF, D’Auria JC. Improved Synthesis of N-Methylcadaverine. Molecules. 2018; 23(5):1216.Chicago/Turabian Style
Anderson, Kayla N.; Moaven, Shiva; Unruh, Daniel K.; Cozzolino, Anthony F.; D’Auria, John C. 2018. "Improved Synthesis of N-Methylcadaverine." Molecules 23, no. 5: 1216.
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