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Molecules 2018, 23(5), 1119;

Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self

Faculty of Biosciences and Aquaculture, Nord University, 8049 Bodø, Norway
Department of Fish Genetics and Biotechnology, ICAR-Central Institute of Fisheries Education, Mumbai 400061, India
Author to whom correspondence should be addressed.
Academic Editors: Ogawa Tomohisa and Tateno Hiroaki
Received: 21 April 2018 / Revised: 5 May 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
Full-Text   |   PDF [237 KB, uploaded 9 May 2018]


Mucosal surfaces are of key importance in protecting animals against external threats including pathogens. In the mucosal surfaces, host molecules interact with non-self to prevent infection and disease. Interestingly, both inhibition and stimulation of uptake hinder infection. In this review, the current knowledgebase on teleost mucosal lectins’ ability to interact with non-self is summarised with a focus on agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing activities. Further research on lectins is essential, both to understand the immune system of fishes, since they rely more on the innate immune system than mammals, and also to explore these molecules’ antibiotic and antiparasitic activities against veterinary and human pathogens. View Full-Text
Keywords: lectin; teleost; mucosal; innate immunology; antibacterial; phagocytosis; agglutination lectin; teleost; mucosal; innate immunology; antibacterial; phagocytosis; agglutination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Brinchmann, M.F.; Patel, D.M.; Pinto, N.; Iversen, M.H. Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self. Molecules 2018, 23, 1119.

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