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Article

Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids

1
Department of Organic Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 4A Chodźki, Lublin 20-093, Poland
2
Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 1 Chodźki, Lublin 20-093, Poland
3
Department of Pharmacology, Faculty of Health Sciences, Medical University of Lublin, 4A Chodźki, Lublin 20-093, Poland
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(5), 1023; https://doi.org/10.3390/molecules23051023
Received: 28 March 2018 / Revised: 13 April 2018 / Accepted: 24 April 2018 / Published: 26 April 2018
(This article belongs to the Section Organic Chemistry)
Series of new thiazolidine-2,4-dione-based chlorophenylthiosemicarbazone hybrids (1740) were synthesized by the reaction of condensation chlorophenylthiosemicarbazides with formylphenyl 2-(2,4-dioxothiazolidin-5-yl/ylidene)acetates. New compounds were tested on reference strains of Gram-positive and Gram-negative bacteria. The antibacterial activity of target compounds was determined by broth dilution method. Most active compounds possess minimum inhibitory concentration (MIC) = 3.91 mg/L. These compounds were non-toxic at concentrations close to their antibacterial effect. The antibacterial activity of some compounds was similar to or higher than the activity of used reference drugs such as oxacillin and cefuroxime. The structure–activity relationships (SARs) analysis collectively suggests that at least two different molecular mechanisms of their antibacterial activity should be expected. View Full-Text
Keywords: thiazolidine-2,4-dione; chlorophenylthiosemicarbazones; antibacterial activity thiazolidine-2,4-dione; chlorophenylthiosemicarbazones; antibacterial activity
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MDPI and ACS Style

Trotsko, N.; Kosikowska, U.; Paneth, A.; Plech, T.; Malm, A.; Wujec, M. Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids. Molecules 2018, 23, 1023. https://doi.org/10.3390/molecules23051023

AMA Style

Trotsko N, Kosikowska U, Paneth A, Plech T, Malm A, Wujec M. Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids. Molecules. 2018; 23(5):1023. https://doi.org/10.3390/molecules23051023

Chicago/Turabian Style

Trotsko, Nazar, Urszula Kosikowska, Agata Paneth, Tomasz Plech, Anna Malm, and Monika Wujec. 2018. "Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids" Molecules 23, no. 5: 1023. https://doi.org/10.3390/molecules23051023

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