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Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops

Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
Author to whom correspondence should be addressed.
Molecules 2018, 23(3), 660;
Received: 23 February 2018 / Revised: 11 March 2018 / Accepted: 14 March 2018 / Published: 15 March 2018
(This article belongs to the Special Issue Biological Activity of Secondary Metabolites)
Hop (Humulus lupulus L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women. Application of 8-PN in the treatment of menopause has been clinically examined with promising results. Other activities that have already been assessed include the potential to prevent bone-resorption or inhibition of tumor growth. On the other hand, the use of phytoestrogens is frequently questioned regarding possible adverse effects associated with long-term consumption. In conclusion, we emphasize the implications of using 8-PN in future treatments of menopausal and post-menopausal symptoms, including the need for precise evidence and further investigations to define the safety risks related to its therapeutic use. View Full-Text
Keywords: 8-prenylnaringenin; menopause; hops; phytoestrogens 8-prenylnaringenin; menopause; hops; phytoestrogens
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MDPI and ACS Style

Štulíková, K.; Karabín, M.; Nešpor, J.; Dostálek, P. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules 2018, 23, 660.

AMA Style

Štulíková K, Karabín M, Nešpor J, Dostálek P. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules. 2018; 23(3):660.

Chicago/Turabian Style

Štulíková, Kateřina, Marcel Karabín, Jakub Nešpor, and Pavel Dostálek. 2018. "Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops" Molecules 23, no. 3: 660.

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