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Molecules 2018, 23(3), 642; https://doi.org/10.3390/molecules23030642

Eudesmane-Type Sesquiterpene Glycosides from Dictamnus dasycarpus Turcz.

1
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
2
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
Received: 2 February 2018 / Revised: 28 February 2018 / Accepted: 9 March 2018 / Published: 13 March 2018
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Abstract

Eudesmane-type sesquiterpenes have been reported to exhibit varieties of biological activities. During the process of investigating this kind of natural product from the root bark of Dictamnus dasycarpus Turcz., 13 eudesmane-type sesquiterpene glycosides including six new isolates, named as dictameudesmnosides A1 (1), A2 (2), B (3), C (4), D (5), and E (6), together with seven known ones (713), were obtained. Herein, their structures were determined by the analysis of physical data, spectroscopic analysis, and chemical methods. The existence of α-configuration glucose units in their structures (15, 8) is not very common in natural glycosidic components. Meanwhile, compounds 35, 7, and 913 displayed TG accumulation inhibitory effects on HepG2 cells. View Full-Text
Keywords: Dictamnus dasycarpus Turcz.; sesquiterpene glycoside; eudesmane-type sesquiterpene; dictameudesmnoside; triglyceride accumulation; HepG2 cell Dictamnus dasycarpus Turcz.; sesquiterpene glycoside; eudesmane-type sesquiterpene; dictameudesmnoside; triglyceride accumulation; HepG2 cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, S.; Li, Z.; Wang, J.; Ruan, J.; Zheng, C.; Huang, P.; Han, L.; Zhang, Y.; Wang, T. Eudesmane-Type Sesquiterpene Glycosides from Dictamnus dasycarpus Turcz.. Molecules 2018, 23, 642.

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