Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus

Xu, Qing-Xia; Hu, Ying; Li, Gui-Yang; Xu, Wei; Zhang, Ying-Tao; Yang, Xiu-Wei

doi:10.3390/molecules23030614

Open AccessArticle

Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus

by

Qing-Xia Xu

¹,

Ying Hu

¹,

Gui-Yang Li

²,

Wei Xu

¹,

Ying-Tao Zhang

^1,* and

Xiu-Wei Yang

^1,*

¹

State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, China

²

Department of Pharmacology, State Province Key Laboratories of Biomedicine and Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, No. 157, Baojian Road, Nangang District, Harbin 150086, China

^*

Authors to whom correspondence should be addressed.

Molecules 2018, 23(3), 614; https://doi.org/10.3390/molecules23030614

Submission received: 14 February 2018 / Revised: 7 March 2018 / Accepted: 7 March 2018 / Published: 8 March 2018

(This article belongs to the Collection Bioactive Compounds)

Download

Browse Figures

Versions Notes

Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is mediated by multiple signaling pathways. In recent years, the components of Psoralea Fructus (PF) have demonstrated some anti-Alzheimer effects both in vitro and in vivo. To further reveal the active compounds of PF and their mechanisms regulating key targets of AD, in this study, we identified four prenylated compounds from the 70% ethanolic aqueous extract of PF, namely bavachin, bavachinin, bavachalcone, and isobavachalcone. Multi-target bioactivity analysis showed that these compounds could differentially inhibit neuroinflammation, oxidative damage, and key AD-related protein targets, such as amyloid β-peptide 42, β-secretase, glycogen synthase kinase 3β, and acetylcholinesterase. These compounds may generate beneficial effects in AD prevention and treatment.

Keywords: Psoraleae Fructus; Alzheimer’s; bavachin; bavachinin; bavachalcone; isobavachalcone; oxidative damage; neuroinflammation; BV-2 microglia; amyloid β-peptide 42

Graphical Abstract

Share and Cite

MDPI and ACS Style

Xu, Q.-X.; Hu, Y.; Li, G.-Y.; Xu, W.; Zhang, Y.-T.; Yang, X.-W. Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus. Molecules 2018, 23, 614. https://doi.org/10.3390/molecules23030614

AMA Style

Xu Q-X, Hu Y, Li G-Y, Xu W, Zhang Y-T, Yang X-W. Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus. Molecules. 2018; 23(3):614. https://doi.org/10.3390/molecules23030614

Chicago/Turabian Style

Xu, Qing-Xia, Ying Hu, Gui-Yang Li, Wei Xu, Ying-Tao Zhang, and Xiu-Wei Yang. 2018. "Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus" Molecules 23, no. 3: 614. https://doi.org/10.3390/molecules23030614

APA Style

Xu, Q.-X., Hu, Y., Li, G.-Y., Xu, W., Zhang, Y.-T., & Yang, X.-W. (2018). Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus. Molecules, 23(3), 614. https://doi.org/10.3390/molecules23030614

Article Menu

Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI