Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola
AbstractTwo new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacterium Labilithrix luteola (DSM 27648T). Additionally, four metabolites 3, 4, 5 and 6 already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal 1H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound 3 had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects. View Full-Text
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Mulwa, L.S.; Jansen, R.; Praditya, D.F.; Mohr, K.I.; Wink, J.; Steinmann, E.; Stadler, M. Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. Molecules 2018, 23, 542.
Mulwa LS, Jansen R, Praditya DF, Mohr KI, Wink J, Steinmann E, Stadler M. Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. Molecules. 2018; 23(3):542.Chicago/Turabian Style
Mulwa, Lucky S.; Jansen, Rolf; Praditya, Dimas F.; Mohr, Kathrin I.; Wink, Joachim; Steinmann, Eike; Stadler, Marc. 2018. "Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola." Molecules 23, no. 3: 542.
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