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Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review

by Kun Yu 1,2,†, Shou-Long Deng 1,†, Tie-Cheng Sun 1, Yuan-Yuan Li 1 and Yi-Xun Liu 1,*
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
National Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(2), 447;
Received: 19 January 2018 / Revised: 10 February 2018 / Accepted: 14 February 2018 / Published: 17 February 2018
Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by Sertoli cells. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular proliferation and energy metabolism and, consequently, can regulate steroidogenesis. These suggest melatonin as a key player in the regulation of steroidogenesis. However, the melatonin-induced regulation of steroid hormones may differ among species, and the literature data indicate that melatonin has important effects on steroidogenesis and male reproduction. View Full-Text
Keywords: melatonin; steroidogenesis; Leydig cell; Sertoli cell melatonin; steroidogenesis; Leydig cell; Sertoli cell
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MDPI and ACS Style

Yu, K.; Deng, S.-L.; Sun, T.-C.; Li, Y.-Y.; Liu, Y.-X. Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review. Molecules 2018, 23, 447.

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