Molecules 2018, 23(2), 369; https://doi.org/10.3390/molecules23020369
Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
Clara Chepkirui 1,†, Winnie C. Sum 2,†, Tian Cheng 1, Josphat C. Matasyoh 3, Cony Decock 4 and Marc Stadler 1,*
1
Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
2
Department of Biochemistry, Egerton University, P.O. BOX 536, Njoro 20115, Kenya
3
Department of Chemistry, Egerton University, P.O. BOX 536, Njoro 20115, Kenya
4
Mycothéque de l’ Universite Catholique de Louvain (BCCM/MUCL), Place Croix du Sud 3, B-1348 Louvain-la-Neuve, Belgium
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Received: 16 January 2018 / Revised: 7 February 2018 / Accepted: 8 February 2018 / Published: 9 February 2018
(This article belongs to the Section Natural Products Chemistry)
Abstract
A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities. View Full-TextKeywords:
cytotoxicity; fungi; Hymenochaetaceae; triterpenes
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Chepkirui, C.; Sum, W.C.; Cheng, T.; Matasyoh, J.C.; Decock, C.; Stadler, M. Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica. Molecules 2018, 23, 369.
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