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Article

Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota

by 1,2,†, 1,2,†, 1,2, 1,2, 1,2, 1,2, 1,2 and 1,2,*
1
Department of Nutrition, School of Public Health, Sun Yat-sen University; Guangzhou 510080, China
2
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 510080, China
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editors: Min-Hsiung Pan and Filomena Conforti
Molecules 2018, 23(12), 3356; https://doi.org/10.3390/molecules23123356
Received: 22 November 2018 / Revised: 11 December 2018 / Accepted: 16 December 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
Promoting the browning of white fat may be a potential means of combating obesity. Therefore, in this study, we investigated the effect of resveratrol (RES) on the body weight and browning of white fat in high-fat diet (HFD)-induced obese mice and the potential associated mechanism in vivo. Eight-week-old male mice were randomized to receive different treatments: (1), chow without any additional treatment (chow); (2), chow plus 0.4% resveratrol (chow-RES); (3), HFD without any additional treatment (HFD); and (4), HFD plus 0.4% resveratrol (HFD-RES). After 4 weeks of feeding, additional 8-week-old male recipient mice were randomly allocated to the following 4 treatments: (5), HFD and received feces from chow-fed mice; (6), HFD and received feces from chow-RES-fed mice; (7), HFD and received feces from HFD-fed mice; and (8), HFD and received feces from HFD-RES-fed mice. RES treatment significantly inhibited increases in fat accumulation, promoted the browning of white adipose tissue (WAT) and alleviated gut microbiota dysbiosis in HFD-fed mice. Subsequent analyses showed that the gut microbiota remodeling induced by resveratrol had a positive role in WAT browning, and sirtuin-1 (Sirt1) signaling appears to be a key component of this process. Overall, the results show that RES may serve as a potential intervention to reduce obesity by alleviating dysbiosis of the gut microbiota. View Full-Text
Keywords: resveratrol; gut microbiota; WAT browning; Sirt1 resveratrol; gut microbiota; WAT browning; Sirt1
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MDPI and ACS Style

Liao, W.; Yin, X.; Li, Q.; Zhang, H.; Liu, Z.; Zheng, X.; Zheng, L.; Feng, X. Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota. Molecules 2018, 23, 3356. https://doi.org/10.3390/molecules23123356

AMA Style

Liao W, Yin X, Li Q, Zhang H, Liu Z, Zheng X, Zheng L, Feng X. Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota. Molecules. 2018; 23(12):3356. https://doi.org/10.3390/molecules23123356

Chicago/Turabian Style

Liao, Weiyao, Xiaohan Yin, Qingrong Li, Hongmin Zhang, Zihui Liu, Xinjie Zheng, Lin Zheng, and Xiang Feng. 2018. "Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota" Molecules 23, no. 12: 3356. https://doi.org/10.3390/molecules23123356

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