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Open AccessArticle

Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota

by Weiyao Liao 1,2,†, Xiaohan Yin 1,2,†, Qingrong Li 1,2, Hongmin Zhang 1,2, Zihui Liu 1,2, Xinjie Zheng 1,2, Lin Zheng 1,2 and Xiang Feng 1,2,*
Department of Nutrition, School of Public Health, Sun Yat-sen University; Guangzhou 510080, China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 510080, China
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editors: Min-Hsiung Pan and Filomena Conforti
Molecules 2018, 23(12), 3356;
Received: 22 November 2018 / Revised: 11 December 2018 / Accepted: 16 December 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
Promoting the browning of white fat may be a potential means of combating obesity. Therefore, in this study, we investigated the effect of resveratrol (RES) on the body weight and browning of white fat in high-fat diet (HFD)-induced obese mice and the potential associated mechanism in vivo. Eight-week-old male mice were randomized to receive different treatments: (1), chow without any additional treatment (chow); (2), chow plus 0.4% resveratrol (chow-RES); (3), HFD without any additional treatment (HFD); and (4), HFD plus 0.4% resveratrol (HFD-RES). After 4 weeks of feeding, additional 8-week-old male recipient mice were randomly allocated to the following 4 treatments: (5), HFD and received feces from chow-fed mice; (6), HFD and received feces from chow-RES-fed mice; (7), HFD and received feces from HFD-fed mice; and (8), HFD and received feces from HFD-RES-fed mice. RES treatment significantly inhibited increases in fat accumulation, promoted the browning of white adipose tissue (WAT) and alleviated gut microbiota dysbiosis in HFD-fed mice. Subsequent analyses showed that the gut microbiota remodeling induced by resveratrol had a positive role in WAT browning, and sirtuin-1 (Sirt1) signaling appears to be a key component of this process. Overall, the results show that RES may serve as a potential intervention to reduce obesity by alleviating dysbiosis of the gut microbiota. View Full-Text
Keywords: resveratrol; gut microbiota; WAT browning; Sirt1 resveratrol; gut microbiota; WAT browning; Sirt1
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MDPI and ACS Style

Liao, W.; Yin, X.; Li, Q.; Zhang, H.; Liu, Z.; Zheng, X.; Zheng, L.; Feng, X. Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota. Molecules 2018, 23, 3356.

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