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Open AccessArticle

Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

Department of Pharmacy, East West University, Dhaka 1212, Bangladesh
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka 1205, Bangladesh
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
School of Cancer and Pharmaceutical Science, King’s College London, 150 Stamford Street, London SE1 9NH, UK
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3288;
Received: 17 October 2018 / Revised: 24 November 2018 / Accepted: 4 December 2018 / Published: 11 December 2018
As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer. View Full-Text
Keywords: endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer
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MDPI and ACS Style

Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288.

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