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Open AccessArticle

Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

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Department of Pharmacy, East West University, Dhaka 1212, Bangladesh
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Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
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Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka 1205, Bangladesh
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Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
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School of Cancer and Pharmaceutical Science, King’s College London, 150 Stamford Street, London SE1 9NH, UK
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3288; https://doi.org/10.3390/molecules23123288
Received: 17 October 2018 / Revised: 24 November 2018 / Accepted: 4 December 2018 / Published: 11 December 2018
As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer. View Full-Text
Keywords: endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer
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MDPI and ACS Style

Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288.

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