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The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats

1
Izmir Biomedicine and Genome Center (IBG), İzmir 35340, Turkey
2
Department of Chemistry, The Graduate School of Natural and Applied Sciences, Dokuz Eylul University, İzmir 35160, Turkey
3
Department of Physiology, Ege University School of Medicine, İzmir 35100, Turkey
4
Department of Chemistry, Division of Biochemistry, Faculty of Science, Dokuz Eylul University, İzmir 35160, Turkey
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3267; https://doi.org/10.3390/molecules23123267
Received: 15 October 2018 / Revised: 12 November 2018 / Accepted: 19 November 2018 / Published: 10 December 2018
(This article belongs to the Special Issue Capsaicin II)
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Abstract

Cisplatin is one of the most active cytotoxic agents in cancer treatment. To clarify the interaction with mitochondria, we hypothesize that the activities of mitochondrial electron transport chain (ETC) enzymes succinate dehydrogenase (SDH) and cytochrome c oxidase (COX), nucleotide levels, as well as levels of catalase (CAT) enzyme and membrane lipid peroxidation (LPO) can be affected by cisplatin. There was a significant decrease of both SDH and COX activities in the lung, heart, and brain tissues at the 1st day after cisplatin exposure, and the observed decreased levels of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) in comparison with the control could be because of cisplatin-induced mitochondrial dysfunction. The investigations suggested that cisplatin inhibits SDH, COX, and ATP synthase. The higher LPO level in the studied tissues after 1 and 4 days post-exposure to cisplatin compared to control can be inferred to be a result of elevated electron leakage from the ETC, and reactive oxygen species (ROS) can lead to wide-ranging tissue damage such as membrane lipid damage. Consequently, it was observed that capsaicin may have a possible protective effect on ETC impairment caused by cisplatin. The activities of SDH and COX were higher in heart and brain exposed to cisplatin + capsaicin compared to cisplatin groups, while LPO levels were lower. The investigated results in the cisplatin + capsaicin groups suggested that the antioxidant capacity of capsaicin scavenges ROS and prevents membrane destruction. View Full-Text
Keywords: cisplatin; capsaicin; ETC; CAT; LPO; ATP–ADP cisplatin; capsaicin; ETC; CAT; LPO; ATP–ADP
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Kursunluoglu, G.; Taskiran, D.; Ayar Kayali, H. The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats. Molecules 2018, 23, 3267.

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