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Open AccessArticle

The Dual Role of Oat Bran Water Extract in Bone Homeostasis Through the Regulation of Osteoclastogenesis and Osteoblast Differentiation

Division of Crop Foundation, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Wanju 55365, Korea
Department of Biological Sciences, College of Natural Science, Chonbuk National University, Jeonju 54896, Korea
Department of Pharmacy, Sunchon National University, Suncheon, Jeonnam 57922, Korea
Forest Biomaterials Research Center, National Institute of Forest Science (NIFS), Jinju, Gyeongnam 52817, Korea
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3119;
Received: 5 November 2018 / Revised: 23 November 2018 / Accepted: 26 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Natural Products Used as Foods and Food Ingredients)
The number of patients with bone metabolic disorders including osteoporosis is increasing worldwide. These disorders often facilitate bone fractures, which seriously impact the patient’s quality of life and could lead to further health complications. Bone homeostasis is tightly regulated to balance bone resorption and formation. However, many anti-osteoporotic agents are broadly categorized as either bone forming or anti-resorptive, and their therapeutic use is often limited due to unwanted side effects. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aims to clarify the bone protecting effects of oat bran water extract (OBWE) and its mode of action. OBWE inhibited RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclast differentiation by blocking c-Fos/NFATc1 through the alteration of I-κB. Furthermore, we found that OBWE enhanced BMP-2-stimulated osteoblast differentiation by the induction of Runx2 via Smad signaling molecules. In addition, the anti-osteoporotic activity of OBWE was also evaluated using an in vivo model. OBWE significantly restored ovariectomy-induced bone loss. These in vitro and in vivo results showed that OBWE has the potential to prevent and treat bone metabolic disorders including osteoporosis. View Full-Text
Keywords: bone; osteoclasts; osteoblasts; oat bran; osteoporosis bone; osteoclasts; osteoblasts; oat bran; osteoporosis
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MDPI and ACS Style

Kim, S.-H.; Kim, K.-J.; Kang, H.J.; Son, Y.-J.; Choi, S.-W.; Lee, M.-J. The Dual Role of Oat Bran Water Extract in Bone Homeostasis Through the Regulation of Osteoclastogenesis and Osteoblast Differentiation. Molecules 2018, 23, 3119.

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