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Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin

1
University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining 835000, China
2
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
3
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Academic Editors: David Barker and Derek J. McPhee
Molecules 2018, 23(11), 3037; https://doi.org/10.3390/molecules23113037
Received: 30 October 2018 / Revised: 12 November 2018 / Accepted: 17 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Lignans)
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Abstract

Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group. View Full-Text
Keywords: aryldihydronaphthalene lignan; arylnaphthalene lignan; oxidation; synthesis aryldihydronaphthalene lignan; arylnaphthalene lignan; oxidation; synthesis
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Xiao, J.; Nan, G.; Wang, Y.-W.; Peng, Y. Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin. Molecules 2018, 23, 3037.

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