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Molecules 2018, 23(11), 2875; https://doi.org/10.3390/molecules23112875

Preparation of Functional Monomers as Precursors of Bioprobes from a Common Styrene Derivative and Polymer Synthesis

1
Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan
2
Medical Innovation Research Unit (MiU), Advanced Institute of Innovative Technology (AIIT), Saitama University, Sakura, Saitama 338-8570, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Lothar Elling
Received: 28 September 2018 / Revised: 25 October 2018 / Accepted: 2 November 2018 / Published: 4 November 2018
(This article belongs to the Section Bioorganic Chemistry)
Full-Text   |   PDF [3221 KB, uploaded 4 November 2018]   |  

Abstract

CM-Str (4-(Chloromethyl)styrene) was used as a useful starting material for the construction of a series of functional monomers. Substitution of the chlorine to the corresponding azide was performed, and the reduction of the azide proceeded smoothly to afford an aminostyrene, which was used as a common precursor for the preparation of functional monomers. Condensation of the amine with a fluorophore, biotin and carbohydrate was accomplished. Among the monomers, a carbohydrate monomer was polymerized with or without acrylamide as a model polymerization to yield the corresponding water-soluble glycopolymers, and biological evaluations of the glycopolymers for a lectin, and wheat germ agglutinin (WGA), were carried out on the basis of the fluorescence change of tryptophan in the WGA. View Full-Text
Keywords: styrene; glycopolymers; radical polymerization; lectins; fluorescence spectrometry styrene; glycopolymers; radical polymerization; lectins; fluorescence spectrometry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hayama, R.; Koyama, T.; Matsushita, T.; Hatano, K.; Matsuoka, K. Preparation of Functional Monomers as Precursors of Bioprobes from a Common Styrene Derivative and Polymer Synthesis. Molecules 2018, 23, 2875.

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