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Open AccessArticle

Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

1
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Salerno, Italy
2
Departament of Psicobiology, University of Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2694; https://doi.org/10.3390/molecules23102694
Received: 29 September 2018 / Revised: 16 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of Lavandula angustifolia (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. An acute intraperitoneal injection of linalool (100 mg/kg) and of LA essential oil (200 mg/kg) reduced motor activity without any anxiolytic effect, but significantly increased social interaction. Stressed mice, after being exposed to a social defeat encounter, showed heightened anxiety and social avoidance. Acute administration of LA essential oil blocked stress-induced anxiety, while linalool showed no effects. However, both compounds were capable of reversing social aversion, acting as antidepressant agents. Our results showed that linalool inhibits pERK and PKA expression in the SH-SY5Y cell, but no effect was detected with the LA essential oil. Therefore, the LA essential oil and linalool may be considered as useful alternative tools to the available traditional treatments for social stress-induced mental illnesses. View Full-Text
Keywords: Lavandula angustifolia; essential oil; linalool; social defeat Lavandula angustifolia; essential oil; linalool; social defeat
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MDPI and ACS Style

Caputo, L.; Reguilon, M.D.; Mińarro, J.; De Feo, V.; Rodriguez-Arias, M. Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat. Molecules 2018, 23, 2694. https://doi.org/10.3390/molecules23102694

AMA Style

Caputo L, Reguilon MD, Mińarro J, De Feo V, Rodriguez-Arias M. Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat. Molecules. 2018; 23(10):2694. https://doi.org/10.3390/molecules23102694

Chicago/Turabian Style

Caputo, Lucia; Reguilon, Marina D.; Mińarro, José; De Feo, Vincenzo; Rodriguez-Arias, Marta. 2018. "Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat" Molecules 23, no. 10: 2694. https://doi.org/10.3390/molecules23102694

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