Next Article in Journal
Fermentation: A Boon for Production of Bioactive Compounds by Processing of Food Industries Wastes (By-Products)
Next Article in Special Issue
Characterization and Prebiotic Potential of Longan Juice Obtained by Enzymatic Conversion of Constituent Sucrose into Fructo-Oligosaccharides
Previous Article in Journal
Ethylenediamine Derived Carboxamides of Betulinic and Ursolic Acid as Potential Cytotoxic Agents
Previous Article in Special Issue
Similarity of Data from Bee Bread with the Same Taxa Collected in India and Romania
Open AccessArticle

Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves

College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Korea
Division of Applied Bioengineering, College of Engineering, Dong-Eui University, Busan 47340, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2018, 23(10), 2559;
Received: 23 August 2018 / Revised: 29 September 2018 / Accepted: 30 September 2018 / Published: 8 October 2018
(This article belongs to the Collection Bioactive Compounds)
The individual parts of Morus alba L. including root bark, branches, leaves, and fruits are used as a cosmetic ingredient in many Asian countries. This study identified several anti-melanogenesis constituents in a 70% ethanol extract of M. alba leaves. The ethyl acetate fraction of the initial ethanol extract decreased the activity of tyrosinase, a key enzyme in the synthetic pathway of melanin. Twelve compounds were isolated from this fraction and their structures were identified based on spectroscopic spectra. Then, the authors investigated the anti-melanogenesis effects of the isolated compounds in B16-F10 mouse melanoma cells. Compounds 3 and 8 significantly inhibited not only melanin production but also intracellular tyrosinase activity in alpha-melanocyte-stimulating-hormone (α-MSH)-induced B16-F10 cells in a dose-dependent manner. These same compounds also inhibited melanogenesis-related protein expression such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein-1 (TRP-1). Compound 3 modulated the cAMP-responsive element-binding protein (CREB) and p38 signaling pathways in α-MSH-activated B16-F10 melanoma cells, which resulted in the anti-melanogenesis effects. These results suggest that compound 3, isolated from M. alba leaves, could be used to inhibit melanin production via the regulation of melanogenesis-related protein expression. View Full-Text
Keywords: Morus alba leaf; anti-melanogenesis; MITF; tyrosinase; TRP-1; TRP-2 Morus alba leaf; anti-melanogenesis; MITF; tyrosinase; TRP-1; TRP-2
Show Figures

Graphical abstract

MDPI and ACS Style

Li, H.X.; Park, J.U.; Su, X.D.; Kim, K.T.; Kang, J.S.; Kim, Y.R.; Kim, Y.H.; Yang, S.Y. Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves. Molecules 2018, 23, 2559.

AMA Style

Li HX, Park JU, Su XD, Kim KT, Kang JS, Kim YR, Kim YH, Yang SY. Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves. Molecules. 2018; 23(10):2559.

Chicago/Turabian Style

Li, Hong X.; Park, Jung U.; Su, Xiang D.; Kim, Kyung T.; Kang, Jong S.; Kim, Young R.; Kim, Young H.; Yang, Seo Y. 2018. "Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves" Molecules 23, no. 10: 2559.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop