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Review

Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin

by
Qing Yao
†,
Meng-Ting Lin
†,
Yin-Di Zhu
,
He-Lin Xu
and
Ying-Zheng Zhao
*
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2018, 23(10), 2547; https://doi.org/10.3390/molecules23102547
Submission received: 2 September 2018 / Revised: 29 September 2018 / Accepted: 1 October 2018 / Published: 6 October 2018
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Abstract

Didymin (isosakuranetin 7-O-rutinoside) is an orally bioactive dietary flavonoid glycoside first found in citrus fruits. Traditionally, this flavonoid has long been used in Asian countries as a dietary antioxidant. Recent studies have provided newer insights into this pleiotropic compound, which could regulate multiple biological activities of many important signaling molecules in health and disease. Emerging data also presented the potential therapeutic application of dietary flavonoid glycoside didymin against cancer, neurological diseases, liver diseases, cardiovascular diseases, and other diseases. In this review, we briefly introduce the source and extraction methods of didymin, and summarize its potential therapeutic application in the treatment of various diseases, with an emphasis on molecular targets and mechanism that contributes to the observed therapeutic effects. The dietary flavonoid didymin can be used to affect health and disease with multiple therapeutic targets, and it is anticipated that this review will stimulate the future development of this potential dietary medicine.
Keywords: didymin; dietary flavonoid glycoside; therapeutic effects; cancer; neurodegenerative disorders didymin; dietary flavonoid glycoside; therapeutic effects; cancer; neurodegenerative disorders
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MDPI and ACS Style

Yao, Q.; Lin, M.-T.; Zhu, Y.-D.; Xu, H.-L.; Zhao, Y.-Z. Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin. Molecules 2018, 23, 2547. https://doi.org/10.3390/molecules23102547

AMA Style

Yao Q, Lin M-T, Zhu Y-D, Xu H-L, Zhao Y-Z. Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin. Molecules. 2018; 23(10):2547. https://doi.org/10.3390/molecules23102547

Chicago/Turabian Style

Yao, Qing, Meng-Ting Lin, Yin-Di Zhu, He-Lin Xu, and Ying-Zheng Zhao. 2018. "Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin" Molecules 23, no. 10: 2547. https://doi.org/10.3390/molecules23102547

APA Style

Yao, Q., Lin, M.-T., Zhu, Y.-D., Xu, H.-L., & Zhao, Y.-Z. (2018). Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin. Molecules, 23(10), 2547. https://doi.org/10.3390/molecules23102547

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