Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance
Abstract
:1. Introduction
2. Results
2.1. Anatomy of the Inner Ear and Gene Delivery
2.2. Advantages and Disadvantages of Administering Vectors into the Inner Ear
2.3. Regeneration of the Sensory Hair Cells
2.4. Preventing Degeneration of Inner Ear Spiral Neurons and Neuron Regeneration
2.5. Development of Endoscope for Topical Administration of Transgenes into Inner Ear
2.6. Problems Associated with Inner Ear Gene Delivery for Clinical Use
2.7. Genetic Hearing Loss
3. Conclusions
Funding
Conflicts of Interest
References
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Viral Vector | Animal | Transfected Cells | RW Penetration | References | |
---|---|---|---|---|---|
via SM | via RW | ||||
ADV | guinea pig | SC, SV, SL | mesenchymal cells in SV/ST | NO | Raphael, Y. 1996 [7]; Weiss, M.A. 1997 [15]; Ishimoto, S. 2002 [5] |
AAV | mouse | IHC, OHC, SC, SG, SL, SV | IHC, OHC, SC, SG, SL, SV | YES | Iizuka, T. 2008 [12]; Shu, Y. et al., 2016 [16] |
AAV | guinea pig | Not reported | spiral limbus, SL, SG, organ of Corti | Lalwani, K. 2000 [17] | |
HSV | guinea pig | Not reported | fibrocytes (types I, II, IV), mesenchymal cells, HCs | NO | Derby, M.L. 1999 [8] |
LV | guinea pig | Not reported | mesenchymal cells in ST | Han, J.J. 1999 [9] | |
SEV | guinea pig | IHC, OHC, SC, | mesenchymal cells in ST | NO | Kanzaki, S. 2007 [10] |
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Kanzaki, S. Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance. Molecules 2018, 23, 2507. https://doi.org/10.3390/molecules23102507
Kanzaki S. Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance. Molecules. 2018; 23(10):2507. https://doi.org/10.3390/molecules23102507
Chicago/Turabian StyleKanzaki, Sho. 2018. "Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance" Molecules 23, no. 10: 2507. https://doi.org/10.3390/molecules23102507