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Molecules 2018, 23(9), 2316; https://doi.org/10.3390/molecules23092316

Recent Advances in Mitochondria-Targeted Gene Delivery

1
and
1,2,3,*
1
Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Korea
2
Institute of Advanced Materials and Systems, Sookmyung Women’s University, Seoul 04310, Korea
3
Research Institute of ICT Convergence, Sookmyung Women’s University, Seoul 04310, Korea
*
Author to whom correspondence should be addressed.
Received: 24 August 2018 / Revised: 6 September 2018 / Accepted: 8 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Gene Delivery)
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Abstract

Mitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial components. However, complete intracellular correction of the mutated genetic parts relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide corrected genetic materials with cells. In this review, we discuss recent novel physical, chemical and biological strategies, and methods to introduce genetic cargos into mitochondria of eukaryotic cells. Effective mitochondria-targeting gene delivery systems can reverse multiple mitochondrial disorders by enabling cells to produce functional mitochondrial components. View Full-Text
Keywords: mitochondrial gene delivery; mitochondrial disease; mitochondrial genomes; heteroplasmy; mitochondrial matrix mitochondrial gene delivery; mitochondrial disease; mitochondrial genomes; heteroplasmy; mitochondrial matrix
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Jang, Y.-H.; Lim, K.-I. Recent Advances in Mitochondria-Targeted Gene Delivery. Molecules 2018, 23, 2316.

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