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Molecules 2018, 23(1), 235; https://doi.org/10.3390/molecules23010235

One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions

1
Department of Pharmacy, Xuanwu Hospital Capital Medical University, Beijing 100053, China
2
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
3
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China
*
Authors to whom correspondence should be addressed.
Received: 15 December 2017 / Revised: 17 January 2018 / Accepted: 19 January 2018 / Published: 22 January 2018
(This article belongs to the Section Organic Chemistry)
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Abstract

A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods. View Full-Text
Keywords: 3-functionalized 4-hydroxycoumarin; multi-component domino reaction; catalyst-free; group-assisted purification process 3-functionalized 4-hydroxycoumarin; multi-component domino reaction; catalyst-free; group-assisted purification process
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, Y.; Zhang, G.-N.; Wang, J.; Bai, X.; Li, Y.; Wang, Y. One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions. Molecules 2018, 23, 235.

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