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Molecules 2018, 23(1), 232; https://doi.org/10.3390/molecules23010232

Chemical Constituents from Apios americana and Their Inhibitory Activity on Tyrosinase

1
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeollabuk-do 56212, Korea
2
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
*
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 2 January 2018 / Accepted: 6 January 2018 / Published: 22 January 2018
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

The goal of this study was to identify phytochemicals with inhibitory activity against tyrosinase. Nine compounds 19 were isolated from the tubers of Apios americana. This is the first report of aromadendrin 5-methyl ether (1) being isolated from the Apios species. Among them, compounds 2 and 8 showed inhibitory activity toward tyrosinase. Based on a Dixon plot, the potential Ki values of competitive inhibitors 2 and 8 were calculated as 10.3 ± 0.8 µM and 44.2 ± 1.7 µM, respectively. An IC50 value of 13.2 ± 1.0 µM was calculated for the slow-binding inhibitor 2 after preincubation with tyrosinase. Additionally, the predicted binding sites between the receptor and ligand, as well as secondary structure changes, in the presence of 2 were examined by molecular simulation. View Full-Text
Keywords: Apios americana; Leguminosae; tyrosinase; slow binding inhibitor; molecular simulation Apios americana; Leguminosae; tyrosinase; slow binding inhibitor; molecular simulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, J.H.; Kim, H.Y.; Kang, S.Y.; Kim, J.-B.; Kim, Y.H.; Jin, C.H. Chemical Constituents from Apios americana and Their Inhibitory Activity on Tyrosinase. Molecules 2018, 23, 232.

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