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Article

Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils

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Faculty of Food Processing Techology, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania
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Faculty of Horticulture and Forestry, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania
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Faculty of Pharmacy, “Victor Babes“ University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square, No. 2, Timisoara 300041, Romania
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Interdisciplinary Research Platform, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania
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Faculty of Agriculture, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania
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Author to whom correspondence should be addressed.
Molecules 2018, 23(1), 185; https://doi.org/10.3390/molecules23010185
Received: 26 November 2017 / Revised: 11 January 2018 / Accepted: 13 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Essential Oils as Antimicrobial and Anti-infectious Agents)
The current study aimed to investigate the chemical composition and the synergistic potential of two essential oils (EOs), as obtained from Salvia officinalis L. (SEO), and Thymus vulgaris L. (TEO). The antifungal potential was tested in vitro against Fusarium graminearum (Fg 06_17), the herbicidal effect was studied using weed seeds of Amaranthus retroflexus (ARET), Chenopodium album (CALB), Echinochloa crus-galli (EGAL), but also wheat seeds (WS) of the Lovrin variety and tomato seeds Saint-Pierre of the variety. The GC-MS profile highlights that the mains compounds identified in SEO were: caryophyllene (25.364%), camphene (14.139%), eucalyptol (13.902%), and β-pinene (11.230%), while in TEO, the predominant phytochemicals were: γ-terpinene (68.415%) and p-thymol (24.721%). The results indicated that the tested EOs alone as well as in combination have allelopathic effect against investigated seeds, while the synergistic effect of TEO and SEO in terms of fungal growth was demonstrated at a level of 0.06%. Thyme and sage EOs exhibited in vitro anti-proliferative activity on two melanoma cell lines, namely A375 human melanoma and B164A5 mouse melanoma alone, as well as in combination. SEO was most effective in terms of decreasing the cell viability of murine and human melanoma cell lines when compared to TEO. View Full-Text
Keywords: Salvia officinalis; Thymus vulgaris; Fusarium graminearum; A375 human melanoma; B164A5 mouse melanoma Salvia officinalis; Thymus vulgaris; Fusarium graminearum; A375 human melanoma; B164A5 mouse melanoma
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MDPI and ACS Style

Alexa, E.; Sumalan, R.M.; Danciu, C.; Obistioiu, D.; Negrea, M.; Poiana, M.-A.; Rus, C.; Radulov, I.; Pop, G.; Dehelean, C. Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils. Molecules 2018, 23, 185. https://doi.org/10.3390/molecules23010185

AMA Style

Alexa E, Sumalan RM, Danciu C, Obistioiu D, Negrea M, Poiana M-A, Rus C, Radulov I, Pop G, Dehelean C. Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils. Molecules. 2018; 23(1):185. https://doi.org/10.3390/molecules23010185

Chicago/Turabian Style

Alexa, Ersilia, Renata M. Sumalan, Corina Danciu, Diana Obistioiu, Monica Negrea, Mariana-Atena Poiana, Cristian Rus, Isidora Radulov, Georgeta Pop, and Cristina Dehelean. 2018. "Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils" Molecules 23, no. 1: 185. https://doi.org/10.3390/molecules23010185

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