H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation
AbstractProtein S-sulfhydration is a newly discovered post-translational modification of specific cysteine residue(s) in target proteins, which is involved in a broad range of cellular functions and metabolic pathways. By changing local conformation and the final activity of target proteins, S-sulfhydration is believed to mediate most cellular responses initiated by H2S, a novel gasotransmitter. In comparison to protein S-sulfhydration, nitric oxide-mediated protein S-nitrosylation has been extensively investigated, including its formation, regulation, transfer and metabolism. Although the investigation on the regulatory mechanisms associated with protein S-sulfhydration is still in its infancy, accumulated evidence suggested that protein S-sulfhydration may share similar chemical features with protein S-nitrosylation. Glutathione persulfide acts as a major donor for protein S-sulfhydration. Here, we review the present knowledge on protein S-sulfhydration, and also predict its formation and regulation mechanisms based on the knowledge from protein S-nitrosylation. View Full-Text
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Ju, Y.; Fu, M.; Stokes, E.; Wu, L.; Yang, G. H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation. Molecules 2017, 22, 1334.
Ju Y, Fu M, Stokes E, Wu L, Yang G. H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation. Molecules. 2017; 22(8):1334.Chicago/Turabian Style
Ju, Youngjun; Fu, Ming; Stokes, Eric; Wu, Lingyun; Yang, Guangdong. 2017. "H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation." Molecules 22, no. 8: 1334.
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