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Molecules 2017, 22(7), 1103;

Synthesis and Fungicidal Activity of 1-(Carbamoylmethyl)-2-aryl-3,1-benzoxazines

Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan University of Science and Technology, Xiangtan 411201, China
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China
Author to whom correspondence should be addressed.
Received: 8 June 2017 / Revised: 25 June 2017 / Accepted: 27 June 2017 / Published: 6 July 2017
(This article belongs to the Section Organic Chemistry)
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A series of new 1-(carbamoylmethyl)-2-aryl-3,1-benzoxazines were prepared in moderate to good yields by BF3·OEt2-catalyzed reactions of aromatic aldehydes with 2-(N-substituted carbamoylmethylamino)benzyl alcohols. The structures of the target compounds were confirmed by IR, 1H-NMR, 13C-NMR, and elemental analyses. The fungicidal activities of the target compounds against plant fungi were preliminarily evaluated, and some of them exhibited good activity. View Full-Text
Keywords: disubstituted-3,1-benzoxazine; heterocycles; synthesis; BF3·OEt2; fungicidal activity disubstituted-3,1-benzoxazine; heterocycles; synthesis; BF3·OEt2; fungicidal activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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    Description: The 1H NMR and 13C NMR Data for compounds.

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Tang, Z.-L.; Wang, L.; Tan, J.-Z.; Wan, Y.-C.; Jiao, Y.-C. Synthesis and Fungicidal Activity of 1-(Carbamoylmethyl)-2-aryl-3,1-benzoxazines. Molecules 2017, 22, 1103.

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