An Expedient Total Synthesis of Triciribine
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. Synthesis of 6-Bromo-4-chloro-5-cyano-7-[2,3,5-tri-O-benzoyl-β-d-ribofuranosyl]pyrrolo[2,3-d]pyrimidine (5)
3.2. Synthesis of 6-Bromo-5-cyano-4-(1-methylhydrazino)-7-[2,3,5-tri-O-benzoyl-β-d-ribofuranosyl]pyrrolo[2,3-d]pyrimidine (6)
3.3. Synthesis of 6-Bromo-5-cyano-4-(2-(tert-butoxycarbonyl)-1-methylhydrazinyl)-7-[2,3,5-tri-O-benzoyl-β-d-ribofuranosyl]pyrrolo[2,3-d]pyrimidine (9)
3.4. Synthesis of 6-Amino-7-bromo-4-methyl-8-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido [4,5-c]pyridazine (10)
3.5. Synthesis of 6-Amino-4-methyl-8-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine (11)
3.6. Synthesis of 6-Amino-4-methyl-8-(β-d-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine (Triciribine, TCN, 1)
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References and Note
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Sample Availability: Samples of all the reported compounds are available from the Prof. Dr. Qiang Xiao. |
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Hu, C.; Ruan, Z.; Ding, H.; Zhou, Y.; Xiao, Q. An Expedient Total Synthesis of Triciribine. Molecules 2017, 22, 643. https://doi.org/10.3390/molecules22040643
Hu C, Ruan Z, Ding H, Zhou Y, Xiao Q. An Expedient Total Synthesis of Triciribine. Molecules. 2017; 22(4):643. https://doi.org/10.3390/molecules22040643
Chicago/Turabian StyleHu, Chen, Zhizhong Ruan, Haixin Ding, Yirong Zhou, and Qiang Xiao. 2017. "An Expedient Total Synthesis of Triciribine" Molecules 22, no. 4: 643. https://doi.org/10.3390/molecules22040643