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Molecules 2017, 22(3), 398;

Implications of Resveratrol on Glucose Uptake and Metabolism

Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 509000, Chile
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4030000, Chile
Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 509000, Chile
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Received: 28 January 2017 / Revised: 21 February 2017 / Accepted: 27 February 2017 / Published: 7 March 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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Resveratrol—a polyphenol of natural origin—has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use of the molecule for medical applications including cancer and type 2 diabetes. Here, we review the latest advances in understanding how resveratrol modulates glucose uptake, regulates cellular metabolism, and how this may be useful to improve current therapies. We discuss challenges and findings regarding the inhibition of glucose uptake by resveratrol and other polyphenols of similar chemical structure. We review alternatives that can be exploited to improve cancer therapies, including the use of other polyphenols, or the combination of resveratrol with other molecules and their impact on glucose homeostasis in cancer and diabetes. View Full-Text
Keywords: resveratrol; polyphenols; glucose transport and metabolism; cancer; diabetes; signal transduction resveratrol; polyphenols; glucose transport and metabolism; cancer; diabetes; signal transduction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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León, D.; Uribe, E.; Zambrano, A.; Salas, M. Implications of Resveratrol on Glucose Uptake and Metabolism. Molecules 2017, 22, 398.

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