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Molecules 2017, 22(2), 323;

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa
Academic Editor: Derek J. McPhee
Received: 26 December 2016 / Revised: 10 February 2017 / Accepted: 15 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue Artemisinin: Against Malaria, Cancer and Viruses)
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Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives. View Full-Text
Keywords: artemisinin; artesunate; artemether; arteether; drug delivery systems artemisinin; artesunate; artemether; arteether; drug delivery systems

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Aderibigbe, B.A. Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives. Molecules 2017, 22, 323.

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