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Molecules 2017, 22(2), 289;

Anti-Hyperglycemic Activity of Major Compounds from Calea ternifolia

Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 18 January 2017 / Revised: 8 February 2017 / Accepted: 9 February 2017 / Published: 14 February 2017
(This article belongs to the Collection Bioactive Compounds)
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Demethylisoencecalin (1) and caleins A (4) and C (5) (3.16–31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during an oral sucrose tolerance test (OSTT, 3 g/kg) in normal and nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those of acarbose (5 mg/kg). During the isolation of 1, 4, and 5, four additional metabolites not previously reported for the plant, were obtained, namely 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3), herniarin (6), scoparone (7), and 4′,7-dimethylapigenin (8). In addition, the structure of calein C (5) was confirmed by X-ray analysis. Pharmacological evaluation of the essential oil of the species (31.6–316.2 mg/kg, p.o.) provoked also an important decrement of blood glucose levels during an OSTT. Gas chromatography coupled with mass spectrometry (GC-MS) analysis of the headspace solid phase microextraction (HS-SPME)-adsorbed compounds and active essential oil obtained by hydrodistillation revealed that chromene 1 was the major component (19.92%); sesquiterpenes represented the highest percentage of the essential oil content (55.67%) and included curcumene (7.10%), spathulenol (12.95%) and caryophyllene oxide (13.0%). A suitable High Performance Liquid Chromatography (HPLC) method for quantifying chromenes 1 and 6-hydroxyacetyl-5-hydroxy-2,2-dimethyl-2H-chromene (2) was developed and validated according to standard protocols. View Full-Text
Keywords: Calea ternifolia; Asteraceae; chromenes; sesquiterpene lactones; antihyperglycemic Calea ternifolia; Asteraceae; chromenes; sesquiterpene lactones; antihyperglycemic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Escandón-Rivera, S.; Pérez-Vásquez, A.; Navarrete, A.; Hernández, M.; Linares, E.; Bye, R.; Mata, R. Anti-Hyperglycemic Activity of Major Compounds from Calea ternifolia. Molecules 2017, 22, 289.

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