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Open AccessArticle

Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01

1
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
2
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Molecules 2017, 22(12), 1999; https://doi.org/10.3390/molecules22121999
Received: 16 October 2017 / Revised: 8 November 2017 / Accepted: 16 November 2017 / Published: 7 December 2017
(This article belongs to the Section Natural Products Chemistry)
Chemical investigation of the fungus Penicillium sp. SCSIO Ind16F01 derived from deep-sea sediment sample afforded a new xanthone, 3,8-dihydroxy-2-methyl-9-oxoxanthene-4-carboxylic acid methyl ester (1) and a new chromone, coniochaetone J (2), together with three known xanthones, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), 7,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (4), 1,6,8-trihydroxy-3-(hydroxymethyl)anthraquinone (5), three known chromones, coniochaetone B (6), citrinolactones B (7), epiremisporine B (8), and four reported rare class of N-methyl quinolone lactams: quinolactacins B (9), C1 (10), and C2 (11), and quinolonimide (12). The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. Those isolated compounds were evaluated for their antiviral (EV71 and H3N2) and cytotoxic activities. View Full-Text
Keywords: marine-derived fungus; Penicillium sp. SCSIO Ind16F01; xanthone; chromone; N-methyl quinolone lactams marine-derived fungus; Penicillium sp. SCSIO Ind16F01; xanthone; chromone; N-methyl quinolone lactams
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Liu, F.-A.; Lin, X.; Zhou, X.; Chen, M.; Huang, X.; Yang, B.; Tao, H. Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01. Molecules 2017, 22, 1999.

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