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Article

Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children

1
Departamento de Fisiología, Facultad de Medicina, Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, 18016-Granada, Spain
2
CIBERfes, Ibs.Granada, and UGC de Laboratorios Clínicos, Complejo Hospitalario de Granada, 18016-Granada, Spain
3
Unidad de Gestión Clínica de Pediatría, Hospital Universitario San Cecilio, 18012-Granada, Spain
*
Author to whom correspondence should be addressed.
Molecules 2017, 22(10), 1728; https://doi.org/10.3390/molecules22101728
Received: 26 September 2017 / Revised: 10 October 2017 / Accepted: 12 October 2017 / Published: 14 October 2017
Charcot-Marie-Tooth neuropathy (CMT) is a motor and sensory neuropathy comprising a heterogeneous group of inherited diseases. The CMT1A phenotype is predominant in the 70% of CMT patients, with nerve conduction velocity reduction and hypertrophic demyelination. These patients have elevated oxidative stress and chronic inflammation. Currently, there is no effective cure for CMT; herein, we investigated whether melatonin treatment may reduce the inflammatory and oxidative damage in CMT1A patients. Three patients, aged 8–10 years, were treated with melatonin (60 mg at 21:00 h plus 10 mg at 09:00 h), and plasma levels of lipid peroxidation (LPO), nitrites (NOx), IL-1β, IL-2, IL-6, TNF-α, INF-γ, oxidized to reduced glutathione (GSSG/GSH) ratio, and the activities of superoxide dismutase (SOD), glutathione-S transferase (GST), glutathione peroxidase (GPx), and reductase (GRd), were determined in erythrocytes at 3 and 6 months of treatment. Healthy age- and sex-matched subjects were used as controls. The results showed increased activities of SOD, GST, GPx, and GRd in CMT1A patients, which were reduced at 3 and 6 months of treatment. The GSSG/GSH ratio significantly increased in the patients, returning to control values after melatonin treatment. The inflammatory process was confirmed by the elevation of all proinflammatory cytokines measured, which were also normalized by melatonin. LPO and NOx, which also were elevated in the patients, were normalized by melatonin. The results document beneficial effects of the use of melatonin in CMT1A patients to reduce the hyperoxidative and inflammatory condition, which may correlate with a reduction of the degenerative process. View Full-Text
Keywords: antioxidant; cytokines; inflammation; melatonin therapy; oxidative stress; axonal neuropathy antioxidant; cytokines; inflammation; melatonin therapy; oxidative stress; axonal neuropathy
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MDPI and ACS Style

Chahbouni, M.; López, M.D.S.; Molina-Carballo, A.; De Haro, T.; Muñoz-Hoyos, A.; Fernández-Ortiz, M.; Guerra-Librero, A.; Acuña-Castroviejo, D. Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children. Molecules 2017, 22, 1728. https://doi.org/10.3390/molecules22101728

AMA Style

Chahbouni M, López MDS, Molina-Carballo A, De Haro T, Muñoz-Hoyos A, Fernández-Ortiz M, Guerra-Librero A, Acuña-Castroviejo D. Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children. Molecules. 2017; 22(10):1728. https://doi.org/10.3390/molecules22101728

Chicago/Turabian Style

Chahbouni, Mariam, María Del Señor López, Antonio Molina-Carballo, Tomás De Haro, Antonio Muñoz-Hoyos, Marisol Fernández-Ortiz, Ana Guerra-Librero, and Darío Acuña-Castroviejo. 2017. "Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children" Molecules 22, no. 10: 1728. https://doi.org/10.3390/molecules22101728

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