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Molecules 2017, 22(1), 27;

Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 08826, Korea
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han and Jian-Xin Pu
Received: 29 November 2016 / Revised: 21 December 2016 / Accepted: 22 December 2016 / Published: 26 December 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
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Activated microglia are known to be a major source of cellular neuroinflammation which causes various neurodegenerative diseases, including Alzheimer’s disease. In our continuing efforts to search for new bioactive phytochemicals against neuroinflammatory diseases, the 80% methanolic extract of Pteris multifida (Pteridaceae) roots was found to exhibit significant NO inhibitory activity in lipopolysaccharide (LPS)-activated BV-2 microglia cells. Three new ent-kaurane diterpenoids, pterokaurane M1 2-O-β-d-glucopyranoside (4), 2β,16α-dihydroxy-ent-kaurane 2,16-di-O-β-d-glucopyranoside (10), and 2β,16α,17-trihydroxy-ent-kaurane 2-O-β-d-glucopyranoside (12), were isolated along with nine other known compounds from P. multifida roots. The chemical structures of the new compounds were determined by 1D- and 2D-NMR, HR-ESI-MS, and CD spectroscopic data analysis. Among the isolates, compounds 1 and 7 significantly inhibited NO production in LPS-stimulated BV-2 cells reducing the expression of the cyclooxygenase-2 (COX-2) protein and the level of pro-inflammatory mediators such as prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. These results suggest that ent-kaurane diterpenes from P. multifida could be potential lead compounds that act as anti-neuroinflammatory agents. View Full-Text
Keywords: Pteris multifida; ent-kaurane diterpenoids; anti-neuroinflammation; nitric oxide (NO); BV-2 microglia Pteris multifida; ent-kaurane diterpenoids; anti-neuroinflammation; nitric oxide (NO); BV-2 microglia

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, J.W.; Seo, J.Y.; Oh, W.K.; Sung, S.H. Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots. Molecules 2017, 22, 27.

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