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Molecules 2016, 21(6), 819;

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Center for Biodiversity and Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, Panama
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
Center for Molecular and Cellular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, Panama
Smithsonian Tropical Research Institute, Balboa, Ancon 0843-03092, Panama
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Salamanca, Ave. Campo Charro, s/n, Salamanca 37007, Spain
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92037, USA
Author to whom correspondence should be addressed.
Academic Editor: Quan-Bin Han
Received: 11 May 2016 / Revised: 17 June 2016 / Accepted: 18 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
PDF [1507 KB, uploaded 22 June 2016]


Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 13 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages. View Full-Text
Keywords: Eunicea succinea; cembranolide diterpenes; uprolides; anti-inflammatory Eunicea succinea; cembranolide diterpenes; uprolides; anti-inflammatory

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Torres-Mendoza, D.; González, Y.; Gómez-Reyes, J.F.; Guzmán, H.M.; López-Perez, J.L.; Gerwick, W.H.; Fernandez, P.L.; Gutiérrez, M. Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea. Molecules 2016, 21, 819.

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