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Article

Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions

College of Chemistry and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, China
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Academic Editor: Derek J. McPhee
Molecules 2016, 21(9), 1232; https://doi.org/10.3390/molecules21091232
Received: 20 July 2016 / Revised: 9 September 2016 / Accepted: 10 September 2016 / Published: 14 September 2016
(This article belongs to the Section Natural Products Chemistry)
Saikosaponin (SS) A is a compound with various pharmacological properties and is easily degraded into SS-B1 and SS-G under acid conditions. In the present work, two new degradation products of SS-A, formed under acid hydrolytic conditions, were detected and isolated using analytical and semi-preparative liquid chromatography technology; furthermore, their structures were characterized as hydroxy-saikosaponin A and SS-B2 by spectral analysis, which is not only essential in stability-indicating method development and validation, but also could be used as a worst case scenario to assess the analytical method performance of SS-A. Moreover, their structural transformation pathways are also proposed. View Full-Text
Keywords: acid hydrolysis; degradation product; saikosaponin A acid hydrolysis; degradation product; saikosaponin A
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MDPI and ACS Style

Li, J.; Xu, Q.; Jiang, H. Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions. Molecules 2016, 21, 1232. https://doi.org/10.3390/molecules21091232

AMA Style

Li J, Xu Q, Jiang H. Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions. Molecules. 2016; 21(9):1232. https://doi.org/10.3390/molecules21091232

Chicago/Turabian Style

Li, Jun, Qiang Xu, and Hua Jiang. 2016. "Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions" Molecules 21, no. 9: 1232. https://doi.org/10.3390/molecules21091232

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