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Molecules 2016, 21(9), 1232;

Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions

College of Chemistry and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 July 2016 / Revised: 9 September 2016 / Accepted: 10 September 2016 / Published: 14 September 2016
(This article belongs to the Section Natural Products Chemistry)
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Saikosaponin (SS) A is a compound with various pharmacological properties and is easily degraded into SS-B1 and SS-G under acid conditions. In the present work, two new degradation products of SS-A, formed under acid hydrolytic conditions, were detected and isolated using analytical and semi-preparative liquid chromatography technology; furthermore, their structures were characterized as hydroxy-saikosaponin A and SS-B2 by spectral analysis, which is not only essential in stability-indicating method development and validation, but also could be used as a worst case scenario to assess the analytical method performance of SS-A. Moreover, their structural transformation pathways are also proposed. View Full-Text
Keywords: acid hydrolysis; degradation product; saikosaponin A acid hydrolysis; degradation product; saikosaponin A

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Li, J.; Xu, Q.; Jiang, H. Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions. Molecules 2016, 21, 1232.

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