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Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2

by Liyan Wang 1,2,*, Yanhua Wu 1,2, Yongtao Chen 1,2, Jiaxin Zou 1,2 and Xiaofan Li 1,2,*
1
Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
2
Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Molecules 2016, 21(7), 883; https://doi.org/10.3390/molecules21070883
Received: 7 June 2016 / Revised: 24 June 2016 / Accepted: 4 July 2016 / Published: 6 July 2016
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 μM) compared with resveratrol (IC50 = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC50 = 78.6 μM and 87.9 μM). View Full-Text
Keywords: resveratrol; prenylation; Aspergillus sp. SCSIOW2; ECD; erythrocyte protection activity; DPPH scavenging activity resveratrol; prenylation; Aspergillus sp. SCSIOW2; ECD; erythrocyte protection activity; DPPH scavenging activity
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MDPI and ACS Style

Wang, L.; Wu, Y.; Chen, Y.; Zou, J.; Li, X. Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2. Molecules 2016, 21, 883.

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