Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
by
Victor Fattori †, Miriam S. N. Hohmann †, Ana C. Rossaneis
, Felipe A. Pinho-Ribeiro and Waldiceu A. Verri *
Victor Fattori †, Miriam S. N. Hohmann †, Ana C. Rossaneis, Felipe A. Pinho-Ribeiro and Waldiceu A. Verri *
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paraná, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Academic Editor: Pin Ju Chueh
Molecules 2016, 21(7), 844; https://doi.org/10.3390/molecules21070844
Received: 27 April 2016 / Accepted: 27 April 2016 / Published: 28 June 2016
(This article belongs to the Special Issue Capsaicin)
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
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Keywords:
analgesia; capsaicinoids; chili peppers; desensitization; TRPV1
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MDPI and ACS Style
Fattori, V.; Hohmann, M.S.N.; Rossaneis, A.C.; Pinho-Ribeiro, F.A.; Verri, W.A. Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules 2016, 21, 844.
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