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Molecules 2016, 21(2), 249;

Synthesis and Characterization of Some New Coumarins with in Vitro Antitumor and Antioxidant Activity and High Protective Effects against DNA Damage

Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt
Faculty of Education; Ain Shams University, Roxy, Cairo 11711, Egypt
All the authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Pascal Richomme
Received: 23 December 2015 / Revised: 2 February 2016 / Accepted: 17 February 2016 / Published: 22 February 2016
(This article belongs to the Special Issue Coumarins, Xanthones and Related Compounds)
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Coumarins are naturally occurring oxygen heterocyclic compounds having multifarious medicinal properties, hence used as lead compounds for designing new potent analogs. The chromene butenoic acid 3 and the benzochromene butenoic acid 4 which are derived from the reaction of glyoxalic acid with 3-acetylcoumarin and 3-acetylbenzocoumarin, respectively, were reacted with different nitrogen and carbon nucleophiles to give new heterocyclic compounds. The structures of the prepared compounds were elucidated by IR, 1H-NMR, and mass spectroscopy. Some of the newly prepared compounds were tested in vitro against a panel of four human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, human prostate cancer PC3, and mammary gland breast MCF-7. Also they were tested as antioxidants. Almost all of the tested compounds showed satisfactory activity. View Full-Text
Keywords: functionalized coumarin; antitumor activity; antioxidant activity functionalized coumarin; antitumor activity; antioxidant activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Salem, M.A.I.; Marzouk, M.I.; El-Kazak, A.M. Synthesis and Characterization of Some New Coumarins with in Vitro Antitumor and Antioxidant Activity and High Protective Effects against DNA Damage. Molecules 2016, 21, 249.

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