Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients
AbstractCytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients and investigated the clinical significance of these changes. IL-27 is a key cellular factor that regulates the differentiation of CD4+ T cells, which can secrete interleukin-10 (IL-10) and interleukin-17 (IL-17) in vivo. Concentrations of serum IL-27 in 67 RA patients, and 36 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Results showed that concentrations of serum IL-27 in all RA patients were significantly higher than in healthy control subjects, and there was a significant and positive correlation between serum IL-27 levels and disease activity in all RA patients. Levels of serum IL-27 in RA patients were significantly correlated with disease activity score in 28 joints (DAS28). Moreover, immunosuppressive treatment with leflunomide downregulated the levels of IL-27 in active RA patients. Therefore, the elevated production of circulating T cell inflammatory factors contributes to the pathogenesis of RA, and serum IL-27 could potentially serve as a new biomarker of RA disease activity. View Full-Text
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Lai, X.; Wang, H.; Cao, J.; Li, Y.; Dai, Y.; Xiang, Y.; Zhang, L. Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients. Molecules 2016, 21, 1565.
Lai X, Wang H, Cao J, Li Y, Dai Y, Xiang Y, Zhang L. Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients. Molecules. 2016; 21(11):1565.Chicago/Turabian Style
Lai, Xiaofei; Wang, Hongxu; Cao, Ju; Li, Ying; Dai, Yubing; Xiang, Yu; Zhang, Liping. 2016. "Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients." Molecules 21, no. 11: 1565.
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