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Molecules 2016, 21(1), 7;

Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice

College of Food Science and Engineering, Jilin University, Changchun 130062, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 October 2015 / Revised: 13 December 2015 / Accepted: 15 December 2015 / Published: 23 December 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1645 KB, uploaded 23 December 2015]   |  


Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions. View Full-Text
Keywords: anti-diabetic; anti-oxidant; anti-hyperlipidemic; corn silk; flavonoids anti-diabetic; anti-oxidant; anti-hyperlipidemic; corn silk; flavonoids

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Zhang, Y.; Wu, L.; Ma, Z.; Cheng, J.; Liu, J. Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice. Molecules 2016, 21, 7.

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