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Molecules 2016, 21(1), 39;

Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-methyl-1-substituted-1H-pyrazoles

Department of Applied Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China
Department of Plant Protection, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 17 August 2015 / Revised: 9 December 2015 / Accepted: 11 December 2015 / Published: 25 December 2015
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [2702 KB, uploaded 25 December 2015]   |  


With the objective of finding valuable herbicidal candidates, a series of new 5-heterocycloxy-3-methyl-1-substituted-1H-pyrazoles were synthesized and their herbicidal activities were evaluated. The bioassay results showed that some compounds exhibited excellent herbicidal activities at the concentration of 100 mg/L, and compound 5-chloro-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)oxy)pyrimidine showed bleaching activity to green weeds. In greenhouse conditions, this compound also showed excellent post-emergence herbicidal effect against Digitaria sanguinalis L. at the dosage of 750 g a. i. ha−1. View Full-Text
Keywords: pyrazole; synthesis; herbicidal activities pyrazole; synthesis; herbicidal activities

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Kang, J.; Yue, X.L.; Chen, C.S.; Li, J.H.; Ma, H.J. Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-methyl-1-substituted-1H-pyrazoles. Molecules 2016, 21, 39.

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