Next Article in Journal
Cold-Setting Inkjet Printed Titania Patterns Reinforced by Organosilicate Binder
Previous Article in Journal
Nanoparticles Biosynthesized by Fungi and Yeast: A Review of Their Preparation, Properties, and Medical Applications
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(9), 16566-16581;

Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities

X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800, Malaysia
Department of Engineering Chemistry, Alva’s Institute of Engineering & Technology, Visvesvaraya Technological University, Mijar, Moodbidri 574225, Karnataka, India
Department of Sugar Technology & Chemistry, University of Mysore, Sir M. V. PG Center, Tubinakere, Mandya 571402, Karnataka, India
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, Kampar 31900, Malaysia
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 July 2015 / Revised: 14 August 2015 / Accepted: 17 August 2015 / Published: 11 September 2015
(This article belongs to the Section Molecular Diversity)
Full-Text   |   PDF [1772 KB, uploaded 11 September 2015]   |  


A series of five new 2‐(1‐benzofuran‐2‐yl)‐2‐oxoethyl 4-(un/substituted)benzoates 4(ae), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3 or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized products 4(ae) were characterized by FTIR, 1H-, 13C- and 1H-13C HMQC NMR spectroscopic analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies. These compounds were screened for their antimicrobial and antioxidant activities. The tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and the highest potency with minimum inhibition concentration (MIC) value of 125 µg/mL was observed for 4e. The results of antioxidant activities revealed the highest activity for compound 4e (32.62% ± 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 4d (31.01% ± 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% ± 1.06%) in metal chelating (MC) activity. View Full-Text
Keywords: benzofuran; spectroscopic analysis; antimicrobial; antioxidant; XRD; substituent benzofuran; spectroscopic analysis; antimicrobial; antioxidant; XRD; substituent

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kumar, C.S.C.; Then, L.Y.; Chia, T.S.; Chandraju, S.; Win, Y.-F.; Sulaiman, S.F.; Hashim, N.S.; Ooi, K.L.; Quah, C.K.; Fun, H.-K. Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. Molecules 2015, 20, 16566-16581.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top