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Molecules 2015, 20(8), 15098-15107;

Addition of CFCl3 to Aromatic Aldehydes via in Situ Grignard Reaction

Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, One Bethel Valley Road, Oak Ridge, TN 37831, USA
Independent Researcher, Juripar, Panjabari, Guwahati 781037, Assam, India
Author to whom correspondence should be addressed.
Academic Editor: Kei Saito
Received: 16 June 2015 / Revised: 29 July 2015 / Accepted: 6 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Frontier in Green Chemistry Approaches)
Full-Text   |   PDF [798 KB, uploaded 18 August 2015]   |  


Synthetic modification of trichlorofluoromethane (CFCl3) to non-volatile and useful fluorinated precursors is a cost-effective and an environmentally benign strategy for the safe consumption/destruction of the ozone depleting potential of the reagent. In this report, we present a novel method for in situ Grignard reaction using magnesium powder and CFCl3 for synthesis of dichlorofluoromethyl aromatic alcohols. View Full-Text
Keywords: CFCl3; magnesium; Grignard reaction; in-situ process; aromatic aldehydes CFCl3; magnesium; Grignard reaction; in-situ process; aromatic aldehydes

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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MDPI and ACS Style

Barkakaty, B.; Talukdar, B.; Lokitz, B.S. Addition of CFCl3 to Aromatic Aldehydes via in Situ Grignard Reaction. Molecules 2015, 20, 15098-15107.

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