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Open AccessArticle

Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
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Academic Editor: Derek J. McPhee
Molecules 2015, 20(7), 12114-12124; https://doi.org/10.3390/molecules200712114
Received: 5 June 2015 / Revised: 21 June 2015 / Accepted: 25 June 2015 / Published: 2 July 2015
(This article belongs to the Section Medicinal Chemistry)
A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets. View Full-Text
Keywords: tadalafil; quantitative analysis; quantitative proton nuclear magnetic resonance; 2,4-dinitrotoluene tadalafil; quantitative analysis; quantitative proton nuclear magnetic resonance; 2,4-dinitrotoluene
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Yang, Q.; Qiu, H.; Guo, W.; Wang, D.; Zhou, X.; Xue, D.; Zhang, J.; Wu, S.; Wang, Y. Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets. Molecules 2015, 20, 12114-12124.

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