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Molecules 2015, 20(6), 9745-9766;

Molecular Interactions of β-(1→3)-Glucans with Their Receptors

Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France
Université européenne de Bretagne, F-35000 Rennes, France
INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France
Department of Pathology, University of Louisville, Louisville, KY 40202, USA
Authors to whom correspondence should be addressed.
Received: 14 April 2015 / Accepted: 20 May 2015 / Published: 27 May 2015
(This article belongs to the Special Issue Protein-Carbohydrate Interactions, and Beyond)
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β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(1→3)-glucans can trigger different immune responses and act as efficient immunostimulating agents. They constitute prevalent sources of carbons for microorganisms after subsequent recognition by digesting enzymes. Nevertheless, mechanisms associated with both roles are not yet clearly understood. This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules. View Full-Text
Keywords: β-(1→3)-glucans; Dectin-1; CR3; glycolipids; langerin; CBM β-(1→3)-glucans; Dectin-1; CR3; glycolipids; langerin; CBM

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Legentil, L.; Paris, F.; Ballet, C.; Trouvelot, S.; Daire, X.; Vetvicka, V.; Ferrières, V. Molecular Interactions of β-(1→3)-Glucans with Their Receptors. Molecules 2015, 20, 9745-9766.

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