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Molecules 2015, 20(6), 10184-10191;

A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin

National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
Department of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 23 April 2015 / Revised: 28 May 2015 / Accepted: 29 May 2015 / Published: 2 June 2015
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [693 KB, uploaded 2 June 2015]   |  


In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4′ and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. View Full-Text
Keywords: scutellarin; scutellarein; 6-O-methylscutellarein; metabolite; synthesis scutellarin; scutellarein; 6-O-methylscutellarein; metabolite; synthesis

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Zhang, W.; Dong, Z.-X.; Gu, T.; Li, N.-G.; Zhang, P.-X.; Wu, W.-Y.; Yu, S.-P.; Tang, Y.-P.; Yang, J.-P.; Shi, Z.-H. A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin. Molecules 2015, 20, 10184-10191.

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